"Combining Enyne Metathesis with Long-Established Organic Transformations: A Powerful Strategy for the Sustainable Synthesis of Bioactive Molecules"

Valerian Dragutan, Ileana Dragutan, Albert Demonceau, and Lionel Delaude

journal cover
          source: Beilstein Journal of Organic Chemistry
            year: 2020
          volume: 16
      first page: 738
       last page: 755
             doi: 10.3762/bjoc.16.68

graphical abstract

Abstract: This account surveys the current progress on the application of intra- and intermolecular enyne metathesis as main key steps in the synthesis of challenging structural motifs and stereochemistries found in bioactive compounds. Special emphasis is placed on ruthenium catalysts as promoters of enyne metathesis to build the desired 1,3-dienic units. The advantageous association of this approach with name reactions like Grignard, Wittig, Diels­Alder, Suzuki­Miyaura, Heck cross-coupling, etc. is illustrated. Examples unveil the generality of such tandem reactions in providing not only the intricate structures of known, in vivo effective substances but also for designing chemically modified analogs as valid alternatives for further therapeutic agents.

Keywords: Bioactive Compounds, Enyne Metathesis, Ring-Closing Metathesis, Ruthenium Catalysts, Tandem Reactions

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